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Related Experiment Videos

Acute phase proteins in tuberculous patients.

C Immanuel1, G S Acharyulu, M Kannapiran

  • 1Tuberculosis Research Centre (Indian Council of Medical Research), Madras.

The Indian Journal of Chest Diseases & Allied Sciences
|January 1, 1990
PubMed
Summary

Serum acute phase proteins like C-reactive protein decreased significantly with tuberculosis treatment across pulmonary, abdominal, and meningitis forms. This indicates their potential as biomarkers for treatment response in tuberculosis patients.

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Area of Science:

  • Biochemistry
  • Immunology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) is a significant global health challenge.
  • Acute phase proteins (APPs) are markers of inflammation and infection.
  • Understanding APP dynamics during TB treatment is crucial for monitoring disease activity.

Purpose of the Study:

  • To investigate the serum concentrations of specific acute phase proteins in patients with different forms of tuberculosis.
  • To evaluate the changes in APP levels during and after anti-TB treatment.
  • To assess the utility of APPs as biomarkers for treatment response and disease activity.

Main Methods:

  • Serum samples were collected from patients with pulmonary, abdominal, and tuberculous meningitis at various time points: admission, during treatment, end of treatment, and 12-month follow-up.

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  • Concentrations of C-reactive protein, ceruloplasmin, haptoglobin, alpha-1-acid glycoprotein, transferrin, and alpha 2-macroglobulin were measured.
  • Statistical analysis was performed to determine significant changes in APP levels.

    • Main Results:

    • Significant decreases in C-reactive protein, ceruloplasmin, haptoglobin, and alpha-1-acid glycoprotein were observed across all three TB groups with treatment.
    • Transferrin levels increased in pulmonary and abdominal TB but decreased in TB meningitis.
    • Alpha 2-macroglobulin did not show consistent acute phase reactant behavior.
    • Proportions of patients with abnormal APP values decreased substantially from admission to end of treatment.

    Conclusions:

    • Serum concentrations of several acute phase proteins decrease significantly with effective tuberculosis treatment.
    • These APPs, particularly C-reactive protein, haptoglobin, and alpha-1-acid glycoprotein, show promise as objective biomarkers for monitoring treatment response in various forms of TB.
    • Further research may validate their role in clinical decision-making for TB management.