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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Systemic lupus erythematosus in identical twins: a case report
Takeshi Kuroda1, Takashi Harada, Yoko Wada
1Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan, kurodat@med.niigata-u.ac.jp
Modern Rheumatology
|October 10, 2006
Summary
Identical twins developed systemic lupus erythematosus (SLE), despite shared genetics and environment. Monitoring one twin allowed early diagnosis and successful treatment of the other, highlighting the importance of vigilant follow-up.
Area of Science:
- Immunology
- Genetics
- Rheumatology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
- Identical twins share nearly identical genetic material.
- Environmental factors are thought to play a role in SLE development.
Purpose of the Study:
- To report a case of identical twins diagnosed with SLE.
- To investigate potential differences in autoantibody profiles and disease manifestations between genetically identical individuals.
- To emphasize the value of early detection through close monitoring.
Main Methods:
- Case study of monozygotic twins.
- Serological testing for autoantibodies (anti-dsDNA, LE test, rheumatoid factor, anti-Scl 70, anti-SSA, anti-ribosomal P).
- Clinical observation and periodic follow-up.
Main Results:
- Both twins presented with high anti-dsDNA antibody titers.
- Only one twin exhibited lupus psychosis and a broader autoantibody profile.
- Early diagnosis and treatment in the second twin prevented disease progression.
Conclusions:
- Genetic identity does not guarantee identical SLE manifestation or autoantibody profiles.
- Environmental factors may influence disease expression.
- Proactive monitoring of at-risk individuals, such as a twin of an SLE patient, is crucial for early diagnosis and management.
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