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Pancreatic response to percutaneous biliary drainage: a prospective study
S J Savader1, A C Venbrux, K V Robbins
1Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, MD 21205.
Radiology
|February 1, 1991
Summary
Percutaneous biliary drainage (PBD) can frequently cause pancreatic insult, leading to hyperamylasemia or pancreatitis. Patient susceptibility to pancreatic issues after PBD is not linked to obstruction severity or disease type.
Area of Science:
- Gastroenterology
- Interventional Radiology
- Pancreatology
Background:
- Percutaneous biliary drainage (PBD) is a common procedure for biliary obstruction.
- The potential impact of PBD on pancreatic function requires further investigation.
Purpose of the Study:
- To evaluate the pancreatic effects of PBD by monitoring serum amylase levels post-procedure.
- To determine the incidence of hyperamylasemia and pancreatitis following PBD.
Main Methods:
- Serum amylase levels were measured for 7 days post-PBD in 50 patients (53 procedures).
- Baseline amylase levels were compared with postprocedural values.
- Patients were monitored for clinical signs of pancreatitis.
Main Results:
- 24% of patients with normal baseline amylase developed asymptomatic hyperamylasemia.
- 10% developed hyperamylasemia with clinical pancreatitis signs.
- Elevated baseline amylase levels decreased post-PBD in some patients.
- Obstruction level and disease type did not predict hyperamylasemia or pancreatitis.
Conclusions:
- Pancreatic insult following PBD may be more frequent than previously recognized.
- Susceptibility to pancreatic complications after PBD is independent of biliary obstruction characteristics.