Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Asynchronous progressive diaphyseal dysplasia.

Toshinori Sakai¹, Yoshito Matsui, Shinsuke Katoh

¹Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Modern Rheumatology

|October 10, 2006

Summary

A rare case of bilateral femora diaphyseal dysplasia was observed in a Japanese woman. The condition presented as cortical thickening and sclerosis, suggesting a potentially unknown bone disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Flexion-dependent differences in tibial rotation measured by navigation and robotic systems during bicruciate-stabilised total knee arthroplasty.

Journal of experimental orthopaedics·2026

Same author

Necrotic-cell-activated macrophages drive an ERK-Bcl-xL survival pathway in osteoclasts and confer bisphosphonate resistance.

Biochemical and biophysical research communications·2026

Same author

Cutoff values of knee extensor strength for stair ascent and descent after bicruciate-stabilized total knee arthroplasty.

Journal of orthopaedics·2026

Same author

Robotic Arm-Assisted Total Knee Arthroplasty for Osteoarthritis Associated with Osteopetrosis: A Case Report.

JBJS case connector·2026

Same author

Is the Posterior Cruciate Ligament Necessary in Cruciate-Substituting Total Knee Arthroplasty? A Cadaveric Comparison of Knee Kinematics With or Without the Posterior Cruciate Ligament Versus the Native Knee.

The Journal of arthroplasty·2026

Same author

Comparison of methods for evaluating soft tissue balance in robotic-assisted total knee arthroplasty: A cadaveric study.

The Knee·2025

Area of Science:

Orthopedics
Radiology
Genetics

Background:

Diaphyseal dysplasia is a group of rare bone disorders affecting long bone shafts.
Distinguishing between different types of diaphyseal dysplasia can be challenging due to overlapping clinical and radiographic features.

Purpose of the Study:

To report an unusual case of diaphyseal dysplasia affecting the bilateral femora.
To discuss the diagnostic challenges and potential pathogenesis of this focal bone abnormality.

Main Methods:

Case report of a 42-year-old Japanese woman.
Radiographic analysis of the femora.

Main Results:

The patient exhibited cortical thickening and sclerosis of the bilateral femora diaphyses.

Related Experiment Videos

Radiographs revealed enlarged diaphyses with indistinct cortical surfaces and no periosteal reaction.

The condition progressed from the left to the right femur over several years.

Conclusions:

The presented case displays features overlapping with Ribbing disease and Camurati-Engelmann disease.
The focal, bilateral involvement of the femora suggests a unique or previously undescribed pathogenic mechanism in diaphyseal dysplasia.