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Updated: Jul 19, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
Looking back at PCPT: looking forward to new paradigms in prostate cancer screening and prevention
Edith Canby-Hagino1, Javier Hernandez, Timothy C Brand
1Department of Urology, University of Texas Health Science Center at San Antonio, TX 78229, USA. canbyhagino@uthscsa.edu
Objectives:
Provide a critical summary of the latest interpretation of findings from the Prostate Cancer Prevention Trial (PCPT).
Methods:
Findings from PCPT and recently published post-hoc analyses are reviewed.
Results:
PCPT demonstrated that finasteride can reduce the prevalence of prostate cancer, permitted the first large-scale assessment of the performance characteristics of prostate-specific antigen for prostate cancer screening, and identified new-onset erectile dysfunction as an early predictor of cardiovascular events.
Conclusions:
PCPT has and will continue to yield valuable information regarding future strategies for prostate cancer prevention and detection, benign prostatic hyperplasia, and other matters of public health importance.
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