Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholestatic syndromes.

M Trauner1, J L Boyer

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Karl Franzens University School of Medicine, Graz, Austria.

Current Opinion in Gastroenterology
|October 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary sclerosing cholangitis: time to rethink imaging criteria for early disease detection.

Journal of hepatology·2026
Same author

Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Anaemia is independently associated with mortality in patients with hepatocellular carcinoma.

ESMO open·2024
Same author

Clinical characteristics and outcome of patients with combined hepatocellular-cholangiocarcinoma-a European multicenter cohort.

ESMO open·2023
Same author

Cancer and hepatic steatosis.

ESMO open·2021
Same author

Impact of high-volume, intermediate-volume and low-volume bowel preparation on colonoscopy quality and patient satisfaction: An observational study.

United European gastroenterology journal·2019
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

New research on hepatobiliary transport proteins improves understanding of cholestatic liver diseases. Genetic mutations causing hereditary syndromes offer insights into bile secretion and cholestasis mechanisms.

Area of Science:

  • Hepatology and Gastroenterology
  • Molecular Biology
  • Genetics

Background:

  • Hepatobiliary transport proteins are crucial for bile secretion.
  • Dysregulation of these proteins contributes to cholestatic liver diseases.
  • Genetic mutations in transporter genes can lead to hereditary cholestatic syndromes.

Purpose of the Study:

  • To elucidate the role of hepatobiliary transport proteins in cholestasis.
  • To understand the pathogenesis of various cholestatic liver diseases.
  • To review recent advancements in the field.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies on genetic mutations and transporter function.
  • Synthesis of findings on disease mechanisms and clinical features.

Related Experiment Videos

Main Results:

  • Insights into the regulation of hepatobiliary transport proteins.
  • Understanding of how transporter gene mutations cause hereditary cholestasis.
  • Comprehensive overview of primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis of pregnancy, TPN-induced cholestasis, and drug-induced cholestasis.

Conclusions:

  • Advances in understanding transporter protein regulation enhance knowledge of cholestatic liver disease pathogenesis.
  • Hereditary cholestatic syndromes provide critical insights into bile secretion and cholestasis.
  • Recent studies offer updated perspectives on the clinical features and treatment of major cholestatic conditions.