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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
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A short water-soluble self-assembling peptide forms amyloid-like fibrils

Sudipta Ray1, Apurba K Das, Michael G B Drew

  • 1Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India.

Chemical Communications (Cambridge, England)
|October 13, 2006
PubMed
Summary

The tripeptide Val-Ile-Ala self-assembles into amyloid-like fibrils, mimicking Alzheimer's disease peptides. In contrast, Ala-Val-Ile forms branched structures without amyloid characteristics.

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