Related Experiment Video
Updated: Jul 19, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Vaccination therapy in prostate cancer
Andrea Marrari1, Manuela Iero, Lorenzo Pilla
1Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy. andrea.marrari@istitutotumori.mi.it
Cancer Immunology, Immunotherapy : CII
|October 13, 2006
Summary
Immunotherapies show promise for recurrent prostate cancer (PC) when standard treatments fail. Harnessing immune cells like dendritic cells and T cells offers new therapeutic avenues for advanced PC.
Area of Science:
- Oncology
- Immunology
- Cancer Therapy
Background:
- Localized prostate cancer (PC) is often controlled by surgery or radiation.
- However, 30-40% of patients experience recurrence within 10 years.
- Effective treatments for advanced, hormone-refractory PC are limited.
Purpose of the Study:
- To review immunotherapeutic strategies for treating or preventing metastatic prostate cancer.
- To assess the feasibility and safety of these novel approaches.
- To discuss the potential of immune-based interventions in PC management.
Main Methods:
- Review of clinical trials exploring immunologic interventions for prostate cancer.
- Focus on strategies involving dendritic cells and tumor-reactive effector lymphocytes.
- Evaluation of treatment feasibility, safety, and clinical responses.
Main Results:
- Several immunotherapeutic strategies have been explored in clinical trials.
- Some approaches have demonstrated clinical responses.
- Vaccine-primed T cells have shown anti-tumor activity in vivo.
Conclusions:
- Immunotherapy, utilizing dendritic cells and T cells, presents a promising alternative for advanced prostate cancer.
- Clinical responses indicate the potential of these immune-based strategies.
- Further research and development are warranted for immunologic interventions in PC patients.
More Related Videos
Related Concept Videos
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...