Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones
Mukund P Sibi1, Jake Zimmerman
1Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA. mukund.sibi@ndsu.edu
Journal of the American Chemical Society
|October 13, 2006
Abstract:
This paper describes a highly site-, diastereo-, and enantioselective intermolecular radical addition/hydrogen atom transfer to hydroxypyrone pyromeconic and kojic acids. The methodology can be extended to the formation of chiral quaternary centers. The products obtained are densely functionalized pyran moieties. The products contain structural features amenable for the introduction of additional substituents.
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