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Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erythematosus
J Arribas1, M Luz Rodríguez, R Alvarez-Do Forno
1Departamento de Bioquímica, Facultad de Medicina de la UAM, Spain.
The Journal of Experimental Medicine
|February 1, 1991
Abstract:
Sera from patients with systemic lupus erythematosus contain specific autoantibodies directed against different polypeptide components of the multicatalytic proteinase (also known as proteasome or prosome). These human autoantibodies, in contrast to polyclonal antibodies obtained in rabbits against the purified enzyme, recognize highly conserved epitopes of the multicatalytic proteinase polypeptides from yeast to human.