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[Colonic perforation in a patient treated with combination chemotherapy for recurrent ovarian clear cell
Kohei Shitara1, Masaki Munakata, Atsushi Ishiguro
1Dept. of Medical Oncology, Misawa City Hospital.
Background:
Colonic perforation due to colitis is a known and reported side effect of chemotherapy.
Case Report:
A 53-year-old woman was treated with combination chemotherapy of irinotecan plus cisplatin for a recurrent ovarian clear cell adenocarcinoma. Steroid was also used for suspected interstitial pneumonia. After two cycles of treatment, she developed a colonic perforation. Emergency laparotomy was not performed because of poor performance status with multiple lung metastases, pleural effusion and pericardial effusion. Colonoscopy showed a perforated wall at the cecum, and a long tube with balloon was inserted for occlusion. In addition, a peritoneal drainage tube was inserted. Oral intake could be restarted for a while, but she died from tumor progression one and a half months after the diagnosis of perforation.
Conclusion:
Non-surgical management with peritoneal drainage and ileus tube was useful in this case of colonic perforation for preserving oral intake and quality of life.
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