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Related Concept Videos

Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

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Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Related Experiment Video

Updated: Jul 19, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Current nutrition in liver disease.

Luis S Marsano1, Anthony E Martin, Henry B Randall

  • 1Department of Medicine, Division of Gastroenterology/Hepatology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA. lsmars01@gwise.louisville.edu

Current Opinion in Gastroenterology
|October 13, 2006
PubMed
Summary

Malnutrition is prevalent in severe liver disease and impacts prognosis. Nutritional interventions are complex but essential, even with hepatic encephalopathy, while obesity poses risks, especially for transplant candidates.

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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Area of Science:

  • Hepatology
  • Clinical Nutrition
  • Gastroenterology

Background:

  • Malnutrition is a frequent complication in severe liver disease, affecting patient outcomes.
  • Assessing malnutrition involves subjective global assessment and objective measures like handgrip strength.
  • The severity of malnutrition correlates with liver disease severity and has prognostic implications.

Purpose of the Study:

  • To review the challenges and considerations in managing malnutrition in severe liver disease.
  • To discuss the role of nutritional support in patients with hepatic encephalopathy.
  • To highlight the impact of obesity on liver transplant candidates.

Main Methods:

  • Literature review of studies on nutrition in liver disease.
  • Analysis of diagnostic methods for malnutrition.
  • Examination of therapeutic strategies for malnutrition and obesity.

Main Results:

  • Malnutrition is multifactorial and difficult to correct, independent of liver injury cause.
  • High-calorie, high-protein diets are recommended for severe malnutrition, even with hepatic encephalopathy.
  • Obesity increases morbidity in liver transplant candidates, necessitating further research on pre-transplant nutritional support.

Conclusions:

  • Effective nutritional management is critical for patients with severe liver disease.
  • Further research is needed on nutritional support efficacy, especially in obesity and pre-transplant settings.
  • Complementary and alternative medicine use requires more scientific validation.