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Malnutrition and Alcohol-Associated Hepatitis.

Craig J McClain1, Cristian D Rios2, Sally Condon2

  • 1Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, USA; UofL Alcohol Research Center, University of Louisville, Louisville, KY, USA; Department of Medicine, University of Louisville, Louisville, KY, USA; Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY, USA; Robely Rex Veterans Affairs Medical Center, Louisville, KY 40207, USA.

Clinics in Liver Disease
|July 7, 2021
PubMed
Summary

Malnutrition is prevalent in alcohol-associated hepatitis (AH), impacting liver health and outcomes. Nutritional support is crucial for improving patient status and reducing complications associated with this condition.

Keywords:
Alcohol-associated hepatitis (AH)MalnutritionMicronutrientsNutritionStandard drink

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Area of Science:

  • Hepatology
  • Nutritional Science
  • Gastroenterology

Background:

  • Malnutrition is a frequent comorbidity in alcohol-associated hepatitis (AH).
  • Severe AH cases almost universally present with some degree of malnutrition.
  • Obesity can mask the classic presentation of sarcopenia in AH patients.

Purpose of the Study:

  • To highlight the significant impact of malnutrition on alcohol-associated hepatitis.
  • To underscore the link between malnutrition and adverse liver outcomes.
  • To emphasize the benefits of nutritional intervention in AH management.

Main Methods:

  • Clinical observation of malnutrition phenotypes in AH.
  • Assessment of caloric intake from alcohol consumption.
  • Correlation of malnutrition with liver complications and outcomes.

Main Results:

  • Alcohol consumption provides "empty calories," contributing to malnutrition despite high intake.
  • Malnutrition is linked to increased risks of hepatic encephalopathy and poorer liver outcomes.
  • Nutritional support demonstrates potential to improve nutritional status and mitigate complications.

Conclusions:

  • Malnutrition is a critical factor in alcohol-associated hepatitis prognosis.
  • Addressing nutritional deficits is essential for managing AH.
  • Early and effective nutrition support can lead to better patient outcomes in AH.