Macrocyclic inhibitors of beta-secretase: functional activity in an animal model

Shawn J Stachel1, Craig A Coburn, Sethu Sankaranarayanan

  • 1Department of Medicinal Chemistry, Biological Chemistry, Molecular Systems and Structural Biology Merck Research Laboratories, Post Office Box 4, West Point, Pennsylvania 19486, USA. shawn_stachel@merck.com