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Related Experiment Videos

Retinoids and wound healing.

Mark Abdelmalek1, James Spencer

  • 1Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19107, USA. markabdelmalek@gmail.com

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|October 13, 2006
PubMed
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Retinoids, used in dermatology, show promising wound healing benefits. Evidence suggests pretreatment with retinoids aids healing after procedures and for various wounds, challenging prior medical-legal standards.

Area of Science:

  • Dermatology
  • Wound Healing Research

Background:

  • Retinoids are common dermatological treatments with debated roles in wound healing.
  • Existing medical-legal standards caution against retinoid use in patients undergoing procedures due to presumed negative impacts.

Purpose of the Study:

  • To critically review existing literature on topical and systemic retinoids in wound healing.
  • To clarify the controversial role of retinoids in the wound healing process.

Main Methods:

  • Literature review of studies on retinoids and wound healing.
  • Critical analysis of evidence for topical and systemic retinoid applications.

Main Results:

  • Pretreatment with retinoids appears to enhance healing post-facial resurfacing and for full- or partial-thickness wounds.

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  • Evidence regarding retinoids on fresh/healing wounds is mixed but predominantly favors beneficial effects.
  • The established medical-legal standard may be premature.

    • Conclusions:

    • Retinoids demonstrate favorable wound-healing properties, particularly with pretreatment.
    • Current medical-legal guidelines regarding retinoid use in surgical patients may require re-evaluation based on scientific evidence.