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Glycopeptide resistance in staphylococci.

K Hiramatsu¹, H Hanaki

¹Department of Bacteriology, Juntendo University, Bunkyo-ku, Tokyo, Japan.

Current Opinion in Infectious Diseases

|October 13, 2006

Summary

Glycopeptide antibiotics are crucial for treating resistant Gram-positive bacteria. This review examines emerging glycopeptide resistance in staphylococci, covering resistance mechanisms, spread, and treatment strategies.

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Area of Science:

Microbiology
Infectious Diseases
Pharmacology

Background:

Glycopeptide antibiotics are vital for treating multidrug-resistant Gram-positive pathogens like methicillin-resistant Staphylococcus aureus (MRSA) and enterococci.
Emerging vancomycin resistance in enterococci and low-level glycopeptide resistance in staphylococci pose significant clinical challenges.

Purpose of the Study:

To review the mechanisms of glycopeptide resistance in staphylococcal strains.
To discuss the epidemiology and control measures for these resistant staphylococci.
To explore current and potential therapeutic options for infections caused by these pathogens.

Main Methods:

Literature review of studies on glycopeptide resistance in staphylococci.
Analysis of epidemiological data on the prevalence of resistant strains.

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Synthesis of information on resistance mechanisms and clinical outcomes.

Main Results:

Staphylococcal strains exhibiting low-level glycopeptide resistance are increasingly reported in clinical settings.
Understanding resistance mechanisms is crucial for developing effective treatment strategies.
Control measures and alternative therapeutic options are needed to combat these infections.

Conclusions:

Glycopeptide resistance in staphylococci represents a growing threat to public health.
Comprehensive strategies encompassing surveillance, infection control, and novel therapeutics are essential.
Further research into resistance mechanisms and treatment efficacy is warranted.