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07:34
Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve
Published on: August 5, 2021
Morphological findings in 192 surgically excised native mitral valves.
Shaun W Leong1, Gursharan S Soor, Jagdish Butany
1Toronto General Hospital, Toronto, Canada.
The Canadian Journal of Cardiology
|October 13, 2006
Summary
Mitral valve disease (MVD) is increasingly common. Postinflammatory (rheumatic) valve disease and myxomatous degeneration are the most frequent causes, with differing patient demographics.
Area of Science:
- Cardiology
- Pathology
Background:
- Mitral valve disease (MVD) presents a growing clinical challenge in the 21st century.
- The underlying pathogenesis of MVD requires further elucidation.
- Understanding evolving MVD causes is crucial for patient management.
Purpose of the Study:
- To investigate the morphological characteristics of native mitral valves requiring surgical excision.
- To identify the primary etiological factors contributing to MVD in the studied population.
- To analyze the demographic differences between patients with distinct MVD causes.
Main Methods:
- Morphological examination of 192 native mitral valves from surgically excised specimens.
- Data collected over a one-year period at Toronto General Hospital.
- Patient age averaged 59.7 years.
Main Results:
- Fibrosis (78.6%) and thickening (66.2%) were the most prevalent leaflet pathologies.
- Commissural fusion (32.3%) and calcification (25.2%) were frequently observed.
- Mitral incompetence affected 57.3% of valves, while stenosis was present in 37.5%.
Conclusions:
- Postinflammatory (rheumatic) valve disease (RVD) was the leading cause (35.9%), followed by myxomatous degeneration (33.3%).
- RVD predominantly affected females (66.7%), whereas myxomatous degeneration was more common in males (76.6%).
- RVD persists as a significant issue, potentially linked to the current patient referral demographics.
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