[Progress and investigation of neuronal plasticity interfered by Borna disease virus infection]

Borna disease virus (BDV) is highly neuronotropic. Recently, more and more investigations indicated that BDV infection was close related to human neuropsychic disorders. However, the mechanism underlying the disorders was unclear to date. Some investigators thought neuronal plasticity changes by BDV infection in the central nervous system may be it's cardinal basis. Many researchers have studied the molecular mechanisms, which might lead to disturbances in neuronal plasticity by BDV infection, through infection-based animal modes such as gerbils modes, rats modes, mice modes and transgenic mice modes. The results showed that neuronal plasticity was interfered by BDV infection through interference with trophic support from astrocytes to neurons, interference with amphoterin signaling and interference with neurotrophin signaling. The disturbances in neuronal plasticity would result in cerebral disorders and cause behavior alterations and psychic alterations of host. In the following years, the ability to manipulate the BDV genome may help uncover unrecognized aspects of the basic mechanisms operating in the regulation of neuronal plasticity of interference with neuronal physiology caused by BDV, give academic foundation for clinical prevention and therapy of BD.