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Plateletapheresis with the new cell separator AS-104
V Kretschmer1, T Middelbeck, A Gerlach
1Abteilung für Transfusionsmedizin und Gerinnungsphysiologie, Universitätsklinikum, Marburg, FRG.
Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1990
Summary
The new AS-104 cell separator offers significant advantages in platelet concentrate separation, improving efficiency, purity, platelet function, and donor safety compared to older systems. This advanced system demonstrates flexibility and reduced operational issues in plateletapheresis.
Area of Science:
- Hematology
- Biomedical Engineering
- Transfusion Medicine
Background:
- Platelet concentrates (PC) are crucial for managing bleeding disorders.
- Optimizing PC separation and quality is essential for effective transfusion therapy.
- Existing cell separation systems have limitations in efficiency and donor safety.
Purpose of the Study:
- To evaluate the performance of the new AS-104 cell separator.
- To compare the AS-104 system with older cell separation technologies.
- To assess the impact of the AS-104 on PC quality, function, and donor safety.
Main Methods:
- Comparative analysis of multiple studies on the AS-104 system.
- Evaluation of 5 different separation protocols.
- Review of data from 580 plateletapheresis procedures.
- Analysis of preliminary transfusion data from 244 transfusions in 49 patients.
Main Results:
- The AS-104 system demonstrated superior separation efficiency and higher purity of platelet concentrates.
- Platelet function and donor safety were significantly improved with the AS-104.
- Reduced frequency of disturbances and discontinuations observed in 580 plateletapheresis runs.
- Comparable posttransfusion increments were achieved with AS-104 derived PC versus CS-3000 derived PC.
Conclusions:
- The AS-104 cell separator represents a significant advancement over older systems.
- The system offers technical flexibility and potential for further development.
- AS-104 enhances the quality and safety of platelet concentrate preparation and transfusion.