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[Comparison of 3 types of cell separators]
R Moog1, G Holtmann, M Holtmann
1Blutspende- und Transfusionsdienst, Universitätsklinikum Essen.
Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1990
Summary
Three cell separators showed comparable platelet yields. However, the V 50 device had a lower thrombocyte count per package, while the AS 104 offered handling and technical advantages for platelet concentrate processing.
Area of Science:
- Biomedical Engineering
- Hematology
- Transfusion Medicine
Background:
- Efficient platelet concentrate processing is crucial for transfusion therapy.
- Commercially available cell separators vary in design and functionality.
- Optimizing thrombocyte yield and quality is a key objective in blood component preparation.
Purpose of the Study:
- To compare the efficiency of three commercial cell separators in terms of thrombocyte yield.
- To evaluate the advantages and disadvantages of different cell separator types.
- To assess the thrombocyte count and plasma volume in processed platelet concentrates.
Main Methods:
- Comparative analysis of three distinct cell separator devices.
- Quantification of total platelets harvested.
- Measurement of thrombocyte count per package and associated plasma volume.
- Statistical analysis to determine significant differences (p=0.05).
Main Results:
- No significant difference was observed in the total number of platelets harvested across all tested cell separators.
- The V 50 device yielded a significantly lower thrombocyte count per package compared to other devices (p=0.05).
- The V 50 device resulted in a larger volume of residual plasma.
Conclusions:
- The tested cell separators demonstrate comparable efficiency for processing platelet concentrates.
- The V 50's higher plasma volume may be a drawback in specific clinical situations.
- The AS 104 presents advantages in handling, processing time, and technical features like ACD flow control and hemolysis detection.