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Spectroscopic analysis of charge transfer complexes between morpholine and iodine
J F Lagorce1, A C Jambut-Absil, J Buxeraud
1Laboratory of Chemical Pharmacy, Faculty of Pharmacy, Limoges University, France.
Chemical & Pharmaceutical Bulletin
|August 1, 1990
Summary
Morpholine forms strong charge-transfer complexes with iodine, indicating its potential for synthesizing new anti-thyroid drugs. This discovery highlights morpholine
Area of Science:
- Chemical Spectroscopy
- Organic Chemistry
- Medicinal Chemistry
Background:
- Nitrogen-containing heterocyclic compounds can form charge-transfer complexes with iodine.
- Donor-acceptor interactions are crucial in chemical complex formation.
Purpose of the Study:
- To investigate the charge-transfer complex formation between morpholine and iodine.
- To determine the stoichiometry and interaction strength of the morpholine-iodine complex.
- To explore the potential of morpholine in synthesizing novel anti-thyroid drugs.
Main Methods:
- Spectroscopic analysis to identify complex formation.
- Determination of complex stoichiometry (1:1).
- Quantification of the formation constant (Kc) in carbon tetrachloride (CCl4) at 20 degrees C.
Main Results:
- Morpholine and iodine form an n-sigma type charge-transfer complex.
- A high formation constant (Kc = 1261 +/- 12 mol-1) was observed.
- The interaction strength significantly exceeds that of aromatic compound-iodine complexes.
Conclusions:
- Morpholine exhibits strong donor-acceptor properties with iodine.
- The potent interaction suggests morpholine as a valuable precursor for novel anti-thyroid drug development.