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Updated: Jul 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Molecularly targeted therapy for melanoma: current reality and future options
Jürgen C Becker1, John M Kirkwood, Sanjiv S Agarwala
1Department of Dermatology, Julius Maximilians University, Würzburg, Germany.
Abstract:
Effective therapy for melanoma remains an unmet goal, with most traditional therapies representing inadequate trade-offs among the several goals of specificity, efficacy, and toxicity. Targeted molecular therapeutics are tailored to genetic abnormalities that are associated with tumor progression. Modulation of aberrant signaling pathways in cancer cells has the potential to provide more effective and potentially nontoxic therapy for a broad range of cancers, including melanoma. Among the possible targets in melanoma are the Ras-MAPK and PI3K/AKT signal transduction pathways, the proteasome, histone deacetylases, methyltransferases, and melanoma-induced angiogenesis.
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