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Updated: Jul 19, 2026

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
Published on: June 2, 2019
Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases
U Smith1, M Laakso, B Eliasson
1The Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. ulf.smith@medic.gu.se
Insights
This summary discusses vascular complications in type 2 diabetes, focusing on macrovascular and microvascular disease. It reviews pathogenesis and treatment strategies for diabetic patients with cardiovascular issues.
Area of Science:
- Endocrinology
- Cardiology
- Diabetology
Background:
- Type 2 diabetes is a major risk factor for vascular complications.
- Macrovascular and microvascular diseases significantly impact patient outcomes.
Observation:
- Case 1: Type 2 diabetes with significant macrovascular disease.
- Case 2: Type 2 diabetes with early microvascular and macrovascular complications.
Findings:
- Discussion on the pathogenesis of vascular complications in diabetes.
- Review of current treatment regimens for diabetic vascular disease.
Implications:
- Understanding pathogenesis aids in developing targeted therapies.
- Optimizing treatment strategies can mitigate diabetic vascular complications.
Abstract:
This publication is a summary of the presentations given at the First JIM Grand Round held at the Sahlgrenska University Hospital on 15 March 2006. The Grand Round was based on two case reports; a patient with type 2 diabetes and pronounced macrovascular disease and another patient with early microvascular disease combined with the macrovascular complications. The pathogenesis of the vascular complications and the current treatment regimens were discussed in relation to the history and examinations performed in these patients.
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