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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Assessing the risk of asthma in infants and pre-school children]
1Departamento de Medicina Respiratoria Infantil, Universidad de Santiago de Chile, Santiago de Chile, Chile. jacastro17@hotmail.com
Insights
Early identification of infants at risk for persistent childhood asthma is crucial. The Asthma Predictive Index aids in identifying infants with recurrent wheezing who may develop long-term asthma and irreversible lung damage.
Area of Science:
- Pediatric pulmonology
- Respiratory medicine
- Inflammatory diseases
Context:
- Childhood asthma presents with diverse wheezing phenotypes and clinical variability.
- Airway inflammation and remodeling are evident early in life, even in infants with persistent wheezing.
- Recurrent wheezing in infancy often precedes persistent asthma.
Purpose:
- To highlight the challenge of identifying infants at risk for persistent asthma.
- To introduce the Asthma Predictive Index as a validated tool for early risk assessment.
- To emphasize the importance of early intervention to prevent irreversible lung damage.
Summary:
- Childhood asthma is a complex inflammatory condition with early onset and progressive airway changes.
- Identifying infants with recurrent wheezing who are prone to persistent asthma is clinically significant.
- The Asthma Predictive Index facilitates early identification of high-risk infants.
Impact:
- Enables timely intervention for infants at risk of developing persistent asthma.
- Aims to mitigate long-term respiratory morbidity and irreversible lung damage.
- Supports proactive management strategies in pediatric respiratory health.
Abstract:
Childhood asthma is a heterogeneous inflammatory disease with several wheezing phenotypes (transient, atopic, nonatopic, and obese) and various clinical expressions of multifactorial origin. All forms, however, follow a similar course characterized by recurrent episodes of airway obstruction. Studies have shown that the onset of disease occurs early in life for the great majority of asthmatics, that airway inflammation and remodeling are present in schoolchildren with asthma, and that even infants with persistent wheezing present airway inflammation. The difficulty lies in the early identification of infants with recurrent wheezing who are at risk of suffering persistent asthma later in life. The Asthma Predictive Index, a simple tool validated in a longitudinal study, has been suggested for early identification of infants with recurrent wheezing who are at risk of developing asthma and whose lung function has undergone major irreversible damage during the first years of life.
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