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Published on: May 26, 2023
Corticosteroid therapy in an alphaviral arthritis
Andrea D Mylonas1, David Harley, David M Purdie
1From the *Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Queensland, Australia; the †Department of Rheumatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia; and the ‡Emergency Department, Prince Charles Hospital, Brisbane, Queensland, Australia.
Corticosteroid use in Ross River virus disease (RRVD) did not worsen symptoms and may speed recovery. This challenges the contraindication of steroids in alphaviral arthritis once immunity is confirmed.
Area of Science:
- Rheumatology
- Infectious Diseases
- Virology
Background:
- Corticosteroids are typically contraindicated in viral arthritis due to immunosuppression risks.
- Concerns include potential for enhanced infection and disease exacerbation.
Purpose of the Study:
- To investigate the impact of oral corticosteroid therapy on Ross River virus disease (RRVD) symptoms.
- To evaluate the safety and efficacy of corticosteroids in managing viral arthritis.
Main Methods:
- Prospective longitudinal studies enrolled patients diagnosed with RRVD.
- Medications, comorbidities, and quality of life (CLINHAQ, SF-36) were assessed.
Main Results:
- No RRVD exacerbation was observed in six patients receiving corticosteroids.
- Corticosteroid users showed faster recovery based on the CLINHAQ Functional Disability Index compared to NSAID users.
Conclusions:
- The contraindication of corticosteroids in alphaviral arthritis may be unwarranted.
- Steroid treatment appears safe and potentially beneficial for RRVD patients with confirmed antiviral immunity.
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