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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Characteristics of occurrence for Han Chinese familial keloids

Yang Chen1, Jian-Hua Gao, Xiao-Jun Liu

  • 1Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, PR China.

Burns : Journal of the International Society for Burn Injuries
|October 19, 2006
PubMed

Insights

Familial keloids in Han Chinese populations often appear spontaneously during puberty, particularly on the chest, back, and shoulders. These keloids exhibit an autosomal dominant inheritance pattern with incomplete penetrance and variable expression.

Area of Science:

  • Dermatology
  • Genetics

Background:

  • Keloids are benign fibroproliferative scars that can cause significant cosmetic and functional issues.
  • Familial keloids suggest a genetic predisposition, but their specific characteristics in different ethnic groups require elucidation.

Purpose of the Study:

  • To characterize the occurrence and inheritance patterns of familial keloids specifically within the Han Chinese population.

Main Methods:

  • Clinical and genetic data from six Han Chinese pedigrees with familial keloids were analyzed.
  • Focus was placed on individuals with no inter-ethnic marriage history to isolate Han Chinese genetic factors.

Main Results:

  • Familial keloids predominantly manifest spontaneously during puberty.
  • Commonly affected areas include the chest, back, and shoulders, with symmetrical distribution and specific shapes.
  • The condition displays variable clinical expression and incomplete penetrance, consistent with autosomal dominant inheritance with reduced penetrance.

Conclusions:

  • Han Chinese familial keloids share distinct occurrence characteristics compared to sporadic cases.
  • The inheritance pattern aligns with autosomal dominant inheritance, featuring incomplete clinical penetrance and variable expression.
Abstract

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