Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baclofen-induced psychosis.

Jatinder Mohan Chawla1, Rajesh Sagar

  • 1Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

The Annals of Pharmacotherapy
|October 19, 2006
PubMed
Summary
This summary is machine-generated.

Therapeutic doses of baclofen may induce psychosis. A patient experienced recurring psychotic symptoms upon baclofen rechallenge, suggesting a probable drug association.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Barriers and Facilitators in the Implementation of the Systematic Medical Appraisal, Referral, and Treatment (SMART) Mental Health Digital Intervention in Rural India: Mixed Methods Process Evaluation Study.

JMIR mental health·2026
Same author

Minimally Guided App-Based Intervention for Nontreatment-Seeking Psychologically Distressed Adults: Protocol for a Randomized Controlled Trial.

JMIR research protocols·2026
Same author

Impact of Repetitive Transcranial Magnetic Stimulation Versus Drug Therapy on Phantom Limb Pain in Traumatic Lower Limb Amputees: A Randomized Controlled Trial.

The Journal of surgical research·2026
Same author

A Meta Analysis of Randomised Controlled Trials on Psychological Interventions for PTSD and Depression in Adolescent Victims of Sexual Abuse.

Clinical child psychology and psychiatry·2026
Same author

Barriers and Facilitators in the Implementation of the Systematic Medical Appraisal, Referral, and Treatment (SMART) Mental Health Digital Intervention in Rural India: Mixed Methods Process Evaluation Study.

JMIR mental health·2026
Same author

Adolescent Mental Health Care and Stigma: The ARTEMIS Randomized Clinical Trial.

JAMA psychiatry·2026

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Baclofen is a muscle relaxant prescribed for spasms.
  • Psychosis is a serious mental health condition characterized by altered reality perception.

Observation:

  • A 32-year-old man developed auditory hallucinations and delusions after 4 weeks of baclofen therapy.
  • Symptoms resolved upon baclofen discontinuation and recurred upon rechallenge.

Findings:

  • The Naranjo scale indicated a probable link between baclofen and the patient's psychosis.
  • This case differs from prior reports due to the absence of underlying mood disorders.

Implications:

  • Baclofen may trigger psychosis, even at therapeutic doses.
  • Clinicians should consider baclofen-induced psychosis in differential diagnoses for new-onset psychosis.