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Oxaliplatin as first-line treatment in inoperable biliary tract carcinoma: a multicenter phase II study
Nikolaos Androulakis1, Gerasimos Aravantinos, Kostas Syrigos
1Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece. georgsec@med.uoc.gr
Background:
A multicenter phase II study was conducted in order to evaluate the efficacy and safety of oxaliplatin as first-line treatment of patients with locally advanced or metastatic carcinoma of the biliary tract.
Patients And Methods:
Twenty-nine chemo-naïve patients with locally advanced or metastatic biliary tract carcinoma received oxaliplatin 130 mg/m(2) i.v. every 21 days. Patients were treated until tumor progression or unacceptable toxicity.
Results:
An objective response (3 complete responses, 3 partial responses) was achieved in 6 patients (20.6%, 95% CI 5.95-35.4). Disease control (complete response, partial response and stable disease) was observed in 14 patients (48.2%). The median time to tumor progression was 3 months (range 0.7-39) and the median overall survival was 7 months (range 1-39). The 1-year survival rate was 32%. Toxicity was mild.
Conclusion:
Oxaliplatin is an active agent against biliary tract carcinoma and therefore should be further investigated in combination with other cytotoxic drugs.