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Related Experiment Videos

Orchestrating ontogenesis: variations on a theme by sonic hedgehog.

Philip W Ingham1, Marysia Placzek

  • 1Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore. pingham@imcb.a-star.edu.sg

Nature Reviews. Genetics
|October 19, 2006
PubMed
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Sonic hedgehog (SHH) protein signaling orchestrates complex embryonic development through sequential cellular interactions. Understanding SHH deployment offers insights into recapitulating organogenesis and cellular programming in vitro.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cellular Biology

Background:

  • Embryonic development generates complexity via sequential cellular interactions.
  • A limited repertoire of signaling molecules mediates these crucial interactions.
  • The diversity of multicellular forms arises from these molecular signaling pathways.

Purpose of the Study:

  • To review the diverse roles of sonic hedgehog (SHH) protein during embryonic development.
  • To elucidate how a limited set of signaling molecules creates organismal form.
  • To provide paradigms for in vitro cellular programming and organogenesis.

Main Methods:

  • Literature review of sonic hedgehog (SHH) protein functions.
  • Analysis of SHH signaling pathways in various embryonic contexts.

Related Experiment Videos

  • Synthesis of examples illustrating SHH's role in inductive interactions.

    • Main Results:

    • Sonic hedgehog (SHH) protein is deployed in multiple ways during embryonic development.
    • SHH signaling mediates key inductive interactions essential for pattern formation.
    • Examples highlight SHH's critical role in establishing diverse cellular and tissue architectures.

    Conclusions:

    • The deployment of SHH protein provides a model for understanding developmental signaling.
    • Insights from SHH function can guide efforts in regenerative medicine and synthetic biology.
    • Understanding SHH mechanisms is key to recapitulating organogenesis in vitro.