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Domino Heck-C-H activation reaction of unsymmetrically substituted [3]cumulene
Takumi Furuta1, Tomohiro Asakawa, Mie Iinuma
1Department of Synthetic Organic & Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
Abstract:
The Heck reaction of an unsymmetrically substituted [3]cumulene has been investigated. Although a carbonyl conjugated alkene is present, the arylpalladium species selectively inserts into the C3-4 double bond, and a subsequent C-H activation reaction with a neighboring phenyl group gives the indene derivatives with a tetrasubstituted olefin moiety.
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