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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
Biodegradable nanomats produced by electrospinning: expanding multifunctionality and potential for tissue
N Ashammakhi1, A Ndreu, A Piras
1Institute of Biomaterials, Tampere University of Technology, Tampere, Finland.
Journal of Nanoscience and Nanotechnology
|October 20, 2006
Summary
Electrospinning creates advanced nanofibers (n-fibers) for tissue engineering scaffolds (n-scaffolds), mimicking natural extracellular matrix. These nanoscaffolds show promise for applications like blood vessel development and drug delivery systems.
Area of Science:
- Nanotechnology
- Biomaterials Science
- Tissue Engineering
Background:
- Nanofibers (n-fibers) produced via electrospinning are gaining traction for tissue engineering applications.
- Nanoscaffolds (n-scaffolds) closely mimic the natural extracellular matrix (ECM) structure.
- Electrospinning techniques have evolved to produce submicron fibers from biodegradable polymers, enabling multifunctional drug-releasing and bioactive scaffolds.
Purpose of the Study:
- To review the electrospinning process for nanofiber scaffold fabrication.
- To discuss factors influencing nanofiber properties and scaffold development.
- To highlight the application of nanoscaffolds in tissue engineering, particularly for blood vessel development.
Main Methods:
- Review of electrospinning techniques and parameters.
- Analysis of substrate, apparatus, and environmental factors affecting nanofiber formation.
- Characterization of developed nanoscaffolds and assessment of cytocompatibility using cell models.
Main Results:
- Nanoscaffolds exhibit properties suitable for tissue engineering constructs.
- Successful testing of nanoscaffold cytocompatibility and cell seeding for tissue development.
- Exploration of nanoscaffold potential for blood vessel engineering.
Conclusions:
- Electrospun nanoscaffolds offer a promising platform for tissue engineering, closely resembling natural ECM.
- Further research into multifunctional scaffolds for controlled drug delivery and various tissue applications is warranted.
- The convergence of nanotechnology, drug release, and tissue engineering is expected to yield enhanced in vivo functionalities for scaffolds.
