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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
Electrospun multifunctional diclofenac sodium releasing nanoscaffold
L Nikkola1, J Seppälä, A Harlin
1Tampere University of Technology, Institute of Biomaterials, Tampere, Finland.
Journal of Nanoscience and Nanotechnology
|October 20, 2006
Summary
Electrospinning successfully created diclofenac sodium (DS) releasing nanofibers for tissue engineering. The porous scaffold shows potential for applications needing rapid control of tissue response.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Nanofibers mimic natural cellular environments, attracting cells for tissue engineering.
- Electrospinning is a versatile technique for creating nanoscale fibers.
Purpose of the Study:
- To manufacture diclofenac sodium (DS) releasing nanofibers using electrospinning.
- To characterize the resulting nanofiber scaffold and its drug release profile.
Main Methods:
- Poly(95 epsilon-capro/5 D,L-lactide) solution with DS was electrospun.
- Nanofiber scaffold properties and DS release kinetics were analyzed.
- UV/VIS spectrophotometry was used to measure DS release.
Main Results:
- Highly porous nanofiber scaffolds (approx. 130 nm diameter) with embedded spheres were produced.
- Approximately 45% of DS was released within the first 24 hours.
- A secondary release phase was observed after 35 days.
Conclusions:
- Electrospinning is a feasible method for producing porous, drug-releasing nanoscaffolds.
- The rapid initial release of DS from these scaffolds may benefit applications requiring immediate control of tissue reactions.
