Jove
Visualize
Contact Us

Related Experiment Videos

Prefrontal cortex dysfunction in patients with suicidal behavior.

Aurelie Raust1, Frédéric Slama, Flavie Mathieu

  • 1Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France.

Psychological Medicine
|October 20, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Empowerment in addictology].

L'Encephale·2026
Same author

Technology-Assisted Training for Ultrasound-Guided Peripheral IV Access by Nurses: A Randomized Educational Study.

Simulation in healthcare : journal of the Society for Simulation in Healthcare·2026
Same author

Risk, reward, and suicide: how impulsivity and loss aversion influence decision-making in individuals who have attempted suicide.

Frontiers in psychiatry·2026
Same author

Tocotrienol-rich vitamin E complex in CADASIL (T3CAD): a randomised, double-blind, placebo-controlled trial.

EClinicalMedicine·2026
Same author

Suicidal crisis: first regulatory approval of IV racemic ketamine.

Lancet (London, England)·2026
Same author

Contribution of the French national health data system to research on mental disorders: A public health perspective - insights from the mental disorders working group of the ReDSiam network.

Journal of epidemiology and population health·2026
Same journal

RDoC cognitive systems and emerging psychopathology: A latent variable analysis of teacher-reported psychosocial difficulties and executive function processes in young children.

Psychological medicine·2026
Same journal

Extreme heat and mental health: systematic review and qualitative investigation of risk and protective factors.

Psychological medicine·2026
Same journal

Glymphatic dysfunction associates with regional white matter hyperintensities and plasma amyloid-β burden across the Alzheimer's disease continuum.

Psychological medicine·2026
Same journal

Mediating effects of healthy lifestyle factors on associations between mental health and functional outcomes in early adolescence.

Psychological medicine·2026
Same journal

Identifying distinct trajectories of change in anhedonia during psychological treatment for depression.

Psychological medicine·2026
Same journal

Functional connectivity correlates of reaction time variability in treatment-resistant major depression.

Psychological medicine·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Patients with suicidal behavior exhibit executive function deficits, particularly in visuospatial skills and inhibition. These findings suggest prefrontal cortex dysfunction in individuals with suicidal behavior.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Abnormal serotonergic neurotransmission is linked to suicidal behavior.
  • The prefrontal cortex (PFC) is extensively studied in suicidal behavior research.
  • Neuropsychological function impairment in suicidal patients requires further investigation.

Purpose of the Study:

  • To investigate prefrontal cortex (PFC)-related neuropsychological functions in patients with suicidal behavior.
  • To differentiate between dorsolateral PFC (DLPFC) and orbitofrontal cortex (OFC)-related functions.

Main Methods:

  • Compared 30 euthymic patients with suicidal behavior (aged 18-65) to 39 controls.
  • Assessed neuropsychological domains: intellectual functioning, reward sensitivity, initiation, inhibition, and working memory.

Related Experiment Videos

  • Used univariate and multivariate analyses, adjusting for covariates like education and mood state.

    • Main Results:

    • Significant executive function deficits were observed in patients with suicidal behavior.
    • Impairments noted in visuospatial conceptualization, spatial working memory, inhibition, and visual attention.
    • Results remained consistent after adjusting for motor impulsivity, with spatial working memory being an exception.

    Conclusions:

    • Observed deficits align with prefrontal cortex dysfunction in suicidal behavior.
    • No specific orbitofrontal region dysfunction was identified in this sample of patients with suicidal behavior.