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Interstitial pulmonary disorders in indium-processing workers.

T Chonan1, O Taguchi, K Omae

  • 1Department of Medicine, Nikko Memorial Hospital, 2-12-8 Kamine-cho, Hitachi, Ibaraki 317-0064, Japan. ttchonan@mbd.ocn.ne.jp

The European Respiratory Journal
|October 20, 2006
PubMed
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Indium exposure may cause lung disease in workers. Increased indium levels correlated with lung abnormalities and higher KL-6 levels, indicating potential occupational lung disease risks.

Area of Science:

  • Occupational Medicine
  • Pulmonary Medicine
  • Toxicology

Background:

  • Indium-tin oxide production is rising due to liquid-crystal panel manufacturing.
  • Reports of interstitial pneumonia in indium workers necessitate further investigation.

Purpose of the Study:

  • To assess the prevalence of interstitial pulmonary disorders in indium workers.
  • To investigate the relationship between indium exposure and lung health indicators.

Main Methods:

  • Study involved 108 male indium workers.
  • Utilized high-resolution computed tomography (HRCT), pulmonary function tests, and serum KL-6 analysis.
  • Measured serum indium concentration.

Main Results:

Related Experiment Videos

  • 23 workers showed significant interstitial changes on HRCT.
  • 40 workers had elevated serum KL-6 levels (>500 U x mL(-1)).
  • Higher serum indium concentrations correlated with longer exposure, increased HRCT changes, reduced lung diffusing capacity, and elevated KL-6.

    • Conclusions:

    • Interstitial lung abnormalities and elevated serum KL-6 are common in indium workers.
    • These findings suggest inhaled indium may cause occupational lung disease.
    • Indium burden is linked to increased prevalence and severity of lung abnormalities.