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Updated: Jul 19, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction
Eun-Ah Bae1, Eun-Kyung Park, Hye-Joung Yang
1College of Pharmacy, Kyung Hee University, Seoul, Korea.
Abstract:
The antiallergic effect of hinokiresinol isolated from the whole plant of TRAPA Pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited beta-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 microM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-alpha in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.
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