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Updated: Jul 19, 2026

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Comparison of creatinine clearance estimates with routine measured clearance
1Service de biochimie, CH Anna Laberge, Biochimie, 200 Brisebois, Châteauguay (Qc), Canada J6K 4W8. guy.planet@rrsss16.gouv.qc.ca
Objectives:
Compare GFR estimates (eGFR) calculated by formulas (CG, CGI, MDRD) and creatinine clearance (CrCl), in subgroups based on sex, age, BMI and serum creatinine (Cr).
Design And Methods:
eGFR is calculated with Cockgroft-Gault (CG), CG corrected for ideal or lean weight (CGI), and Modification of Diet in Renal Disease (MDRD) formulas using a compensated kinetic Jaffé method. Comparison of means and correlations relative to CrCl is done with 666 male and female adult subjects in different subgroups.
Results:
Comparatively to CrCl, most subgroups are best correlated with MDRD, especially with high Cr. However, in men <65 years, a factor of 222, instead of 186 in MDRD formula, is better.
Conclusions:
eGFR from MDRD formula, modified for men <65 years, is better correlated to CrCl.
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