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Related Experiment Video

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In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Vaccines for preventing malaria (pre-erythrocytic).

P Graves¹, H Gelband

¹EpiVec Consulting, 606 Kimberly Lane NE, Atlanta, GA 30306, USA. epivec@comcast.net

The Cochrane Database of Systematic Reviews

|October 21, 2006

Summary

The RTS,S malaria vaccine effectively reduced clinical and severe malaria episodes in children and adults. No severe adverse events were linked to RTS,S, supporting its progression towards licensing.

Area of Science:

Vaccinology
Infectious Diseases
Tropical Medicine

Background:

Development of malaria vaccines targets Plasmodium falciparum, the most severe malaria-causing parasite.
Pre-erythrocytic vaccines aim to prevent malaria by targeting the sporozoite and liver stages.

Purpose of the Study:

To evaluate the efficacy and safety of pre-erythrocytic malaria vaccines in humans.
To assess protection against any form of human malaria.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials.
Searched multiple databases (Cochrane, MEDLINE, EMBASE, LILACS, SCI) and contacted experts.
Included trials comparing pre-erythrocytic vaccines with placebo or control measures.

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Published on: May 18, 2016

Main Results:

RTS,S vaccine reduced clinical malaria by 26% and severe malaria by 58% in semi-immune children for up to 18 months.
RTS,S also reduced clinical malaria by 63% in semi-immune adult men after a booster dose.
Other vaccines (CS-NANP, CS102, ME-TRAP) showed no significant effect; RTS,S had increased minor adverse events like injection site pain.

Conclusions:

RTS,S vaccine demonstrates efficacy in preventing clinical and severe malaria, particularly in children.
No severe adverse events were attributed to the RTS,S vaccine, justifying its continued development.
Other malaria vaccines evaluated showed limited promise, highlighting the need for further research.