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Inflammatory bowel disease: Pandora's box, present and future

Jürgen Schölmerich1

  • 1Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, D-93042 Regensburg, Germany. juergen.schoelmerich@klinik.uni-r.de

Annals of the New York Academy of Sciences
|October 24, 2006
PubMed

Current treatment of inflammatory bowel disease is rather effective through it is only working in symptomatic fashion. Most recombinant "biologicals" have not been an overwhelming success. Infliximab has shown clinically relevant efficacy and is used in patients not responding to the standards. Alternatives such as modulating the bacterial-epithelial interaction, tightening of the mucosal barrier and maybe even immunostimulation should be studied since most recent finding on etiology and pathophysiology point to a disturbed barrier with consequent abnormal bacterial epithelial interaction as the main problem in the IBD syndrome. We still need to learn much but we should not focus only on immunosuppressive systems.

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