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Updated: Jul 19, 2026

Detection of DNA Double-Stranded Breaks in Mouse Oocytes
Published on: June 23, 2023
[Oocyte capacity to repair DNA damage induced in sperm]
1Institut Rhônalpin, Centre de FIV - Clinique du Val d'Ouest, 69130 Ecully.
Abstract:
Germ cells perform a unique and critical biological function: they propagate the DNA that will be used to direct development of the next generation. Genetic integrity of germ cell DNA is essential for producing healthy and reproductively fit offspring. There is accumulating evidence that genetic damage, in the form of unrepaired DNA lesions or de novo mutations, may be transmitted via sperm to offspring. Such genetic damage may arise from environmental exposure or via endogenously formed reactive species, in stem cells or during spermatogenesis. Based on results from our own and other laboratories, we discuss the current knowledge of different pathways of DNA repair, especially in human oocyte.
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