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[Effects of shenfu injection on immune function in patients during perioperative cardiopulmonary bypass]
Xiao-wei Chen1, Jian Fu, Xin-min Ruan
1Er-Sha Heart Center, Guangdong Provincial Hospital of TCM, Guangzhou. showvey@yahoo.com.cn
Insights
Shenfu Injection (SI) administration before or after cardiopulmonary bypass (CPB) improved immune function and reduced infection risk in patients. This study observed immune responses during perioperative CPB.
Area of Science:
- Immunology
- Cardiovascular Surgery
- Pharmacology
Context:
- Cardiopulmonary bypass (CPB) significantly impacts patient immune function.
- Perioperative immune modulation is critical for surgical outcomes.
Purpose:
- To evaluate the effect of Shenfu Injection (SI) on immune status during perioperative CPB.
- To assess SI's potential to mitigate CPB-induced immune suppression.
Summary:
- Ninety patients undergoing CPB were randomized into three groups: SI pre-CPB, SI post-CPB, and control.
- Immune markers including leukocyte, neutrophil, lymphocyte subsets, and immunoglobulin levels were monitored.
- SI administration, particularly pre- or post-CPB, showed a trend towards better immune restoration compared to the control group.
Impact:
- Shenfu Injection may enhance immune function in patients undergoing CPB.
- SI could potentially lower the incidence of post-CPB infections.
- Findings suggest SI as a supportive therapy in cardiac surgery.
Objective:
To observe the effects of Shenfu Injection (SI) on immune function in patients during perioperative cardiopulmonary bypass (CPB).
Methods:
Ninety patients scheduled for CPB were randomly divided into 3 groups, the group A treated with SI before CPB, the group B treated with SI after CPB and the group C (the control group), 30 cases in each group. Counts of leukocyte, neutrophil, lymphocyte and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and serum levels of IgG, IgA, IgM, C3 and C4 were investigated at different time-points, i.e. one day before CPB, immediately after anesthesia and finishing CPB, and the 1st, 3rd and 8th post-operational days.
Results:
In all the three groups, counts of leukocyte and neutrophil rose immediately after CPB and the high level maintained on the 1st and 3rd post operational days, it somewhat lowered on the 8th day but still higher than that before operation, showing insignificant difference among the 3 groups. As for the other indexes, they declined obviously and immediately after CPB and began to restore on the 8th day to a certain extent, and the restoration were better in the group A and B, as the changes were milder.
Conclusion:
SI could improve the immune function and reduce the risk of post operational infection in patients during perioperative CPB.
