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[Albuminuria and cardiovascular risk: basal results of the KORAL-CARDIO study]

J R González-Juanatey1, E Alegría, J L Zamorano

  • 1Hospital Clínico Universitario de Santiago. jose.ramon.gonzalez.juanatey@sergas.es

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|October 25, 2006
PubMed

Insights

Patients with hypertension, heart disease, and albuminuria frequently experience cardiovascular complications. Blood pressure management was inadequate in this high-risk group, highlighting the need for better treatment strategies.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Context:

  • Albuminuria signifies increased cardiovascular and renal risk in hypertensive patients.
  • Renin-angiotensin system inhibitors are crucial for managing hypertension with albuminuria.
  • The KORAL-CARDIO study focused on patients with hypertension, cardiac disease, and albuminuria, not previously on angiotensin inhibitors.

Purpose:

  • To evaluate the clinical characteristics and management of hypertensive patients with cardiac disease and albuminuria.
  • To identify associated cardiovascular and metabolic complications in this patient cohort.

Summary:

  • The study included 2711 hypertensive patients, 42% with type 2 diabetes, and albuminuria.
  • Macroalbuminuria prevalence was higher in diabetics (12.7%) than non-diabetics (7.2%).
  • High rates of obesity, ischemic heart disease, stroke, atrial fibrillation, and hypercholesterolemia were observed. Antihypertensive monotherapy was common, with inadequate triple therapy use.

Impact:

  • Cardiovascular complications are highly prevalent in hypertensive patients with heart disease and albuminuria.
  • Inadequate blood pressure control was evident in the studied population.
  • Findings underscore the need for improved management strategies, including renin-angiotensin system blockade, for this high-risk group.
Abstract

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