Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Middle molecules removal. Beyond beta2-microglobulin].

F Maduell1, J J Sánchez-Canel, J A Blasco

  • 1Servicio de Nefrología, Hospital General de Castellón. maduell_fra@gva.es

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|October 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addressing Critical Fungal Pathogens Under a One Health Perspective: Key Insights from the Portuguese Association of Medical Mycology.

Mycopathologia·2025
Same author

Proof of concept for a nonadditive stochastic model of supercooled liquids.

Physical review. E·2024
Same author

Polythylene glycol severe allergy and SARS-CoV-2 vaccines: usefulness of testing with PEG 1500 extract.

European annals of allergy and clinical immunology·2022
Same author

Small-scale agricultural grassland management can affect soil fungal community structure as much as continental scale geographic patterns.

FEMS microbiology ecology·2021
Same author

Anaphylactic shock to iodinated contrast media: not so rare after all.

European annals of allergy and clinical immunology·2021
Same author

A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial.

Trials·2021

High-flux hemodialysis and online hemodiafiltration effectively remove uremic toxins, especially larger molecules. Newer filter generations significantly enhance the removal of toxins like alpha1-microglobulin compared to older filters.

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Renal Replacement Therapy

Background:

  • Uremic toxin removal is crucial for hemodialysis patients.
  • Dialyzer type and hemodialysis modality significantly impact toxin clearance.
  • High-flux hemodialysis and hemodiafiltration offer enhanced solute removal compared to low-flux options.

Purpose of the Study:

  • To compare the removal of large uremic toxins, specifically those larger than beta2-microglobulin, using high-flux hemodialysis (HD) and on-line hemodiafiltration (OL-HDF).
  • To evaluate the efficacy of different dialyzer membranes (polisulfone HF80, polyethersulfone Arylane H9, and new polisulfone APS 900) in removing various uremic toxins.
  • To assess toxin removal in patients undergoing both standard thrice-weekly and short daily hemodialysis regimens.

Main Methods:

Related Experiment Videos

  • A study involving 24 hemodialysis patients (12 standard, 12 short daily dialysis).
  • Patients underwent three sessions of high-flux HD and three sessions of OL-HDF using three different dialyzer types.
  • Pre- and post-dialysis concentrations of urea, creatinine, beta2-microglobulin, myoglobin, prolactin, and alpha1-microglobulin were measured.

Main Results:

  • No significant difference in small molecule removal (urea, creatinine) between HD and OL-HDF.
  • Beta2-microglobulin removal was higher with OL-HDF (81%) than HD (68%).
  • Newer filters (Arylane, APS) showed superior removal of myoglobin and prolactin compared to older polisulfone filters.
  • Alpha1-microglobulin reduction was significantly higher with OL-HDF (22%) than HD (6%), with the APS 900 filter achieving 35.4% removal.

Conclusions:

  • Newer generation dialyzer filters demonstrate improved removal of uremic toxins, particularly larger molecules exceeding beta2-microglobulin.
  • On-line hemodiafiltration, especially with advanced filters like APS 900, is a more effective modality for clearing large molecular weight toxins compared to high-flux hemodialysis.
  • Dialyzer technology plays a critical role in optimizing uremic toxin removal in hemodialysis patients.