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Published on: June 26, 2018
[Studies on active substance of anticancer effect in Polygonum cuspidatum]
Lei Feng1, Lian-fen Zhang, Ting Yan
1The Biopharmaceutical Laboratory, School of Biotechnology, Yangtze University, Wuxi, China. feng2000lei@yahoo.com.cn
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|October 25, 2006
Summary
Resveratrol, isolated from Polygonum cuspidatum, effectively inhibits cancer cell proliferation with low toxicity. This natural compound shows promise as a novel anticancer agent.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Cancer Biology
Background:
- Polygonum cuspidatum is a traditional medicinal plant.
- Research into its medicinal value is ongoing.
- Identifying active compounds is crucial for drug development.
Purpose of the Study:
- To isolate and identify bioactive compounds from Polygonum cuspidatum.
- To evaluate the anticancer potential of isolated compounds.
- To provide a scientific basis for the medicinal use of Polygonum cuspidatum.
Main Methods:
- Cytotoxicity-guided fractionation of Polygonum cuspidatum root extract.
- Identification of the active compound using HPLC-MS, UV, and IR spectroscopy.
- Assessment of cell growth inhibition (MTT assay) and morphological changes (HE staining) in various cancer and normal cell lines.
Main Results:
- Trans- and cis-resveratrol were identified as the key bioactive compounds.
- Resveratrol demonstrated specific inhibition of cancer cell proliferation (Hep G2, SHZ-888, MCF-7, MCF-7/ADM).
- Normal human liver cells (L-02) showed resistance to resveratrol's effects, indicating selectivity.
Conclusions:
- Resveratrol is a potent anticancer compound found in Polygonum cuspidatum.
- It exhibits high efficacy and low toxicity against cancer cells.
- Resveratrol represents a promising candidate for novel anticancer drug development.
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