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Updated: Jul 19, 2026

Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis
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Physical training attenuates the stress-induced changes in rat T-lymphocyte function.

Carol Góis Leandro1, Thais Martins de Lima, Alessandra Folador

  • 1Superior School of Physical Education, Federal University of Pernambuco, Recife, Brazil.

Neuroimmunomodulation
|October 26, 2006
PubMed
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Moderate physical training can protect T-lymphocyte function from acute stress. Trained rats showed no stress-induced changes in T-lymphocyte apoptosis or proliferation, unlike untrained rats.

Area of Science:

  • Immunology
  • Stress Physiology
  • Exercise Science

Background:

  • Stress significantly impacts immune function, particularly T-lymphocyte responses.
  • Acute restraint stress can impair T-lymphocyte function.
  • Moderate physical training is known to have positive effects on the immune system.

Purpose of the Study:

  • To investigate the impact of moderate physical training on T-lymphocyte function in rats subjected to acute restraint stress.
  • To determine if physical training can mitigate stress-induced immunological changes.

Main Methods:

  • Thirty male Wistar rats were divided into trained and non-trained groups, with subgroups exposed to acute restraint stress.
  • Trained rats underwent 8 weeks of moderate running.
  • Evaluated plasma corticosterone, leukocyte counts, T-lymphocyte apoptosis, and T-lymphocyte proliferation.

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Restraint to Induce Stress in Mice and Rats
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Restraint to Induce Stress in Mice and Rats

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Main Results:

  • Acute stress elevated corticosterone in non-trained rats but not in trained rats.
  • Restraint stress increased T-lymphocyte apoptosis and decreased proliferation in non-trained rats.
  • Trained rats exposed to stress showed no significant alterations in T-lymphocyte apoptosis or proliferation.

Conclusions:

  • Acute restraint stress negatively affects T-lymphocyte function.
  • Moderate physical training attenuates the adverse effects of acute stress on T-lymphocytes.
  • The protective mechanism involves the hypothalamic-pituitary-adrenal axis and enhanced leukocyte tolerance.