Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrolyte transport in the lungs.

H A Berger1, M J Welsh

  • 1Howard Hughes Medical Institute, University of Iowa, Iowa City.

Hospital Practice (Office Ed.)
|March 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

Genes, brain, and behavior·2013
Same author

Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning.

Genes, brain, and behavior·2011
Same author

The piglet as a model for B cell and immune system development.

Veterinary immunology and immunopathology·2008
Same author

Endothelial barrier dysfunction caused by LPS correlates with phosphorylation of HSP27 in vivo.

Cell biology and toxicology·2004
Same author

Don't overlook condoms for HIV prevention.

Sexually transmitted infections·2003
Same author

cAMP stimulation of HCO3- secretion across airway epithelia.

JOP : Journal of the pancreas·2002

Cystic fibrosis, a genetic disease, involves abnormal sodium and chloride transport, leading to dehydrated lung mucus. Understanding these transport mechanisms is key to addressing the disease

Area of Science:

  • Physiology
  • Genetics
  • Molecular Biology

Background:

  • Transepithelial ion transport is vital for physiological functions.
  • Cystic fibrosis is a lethal genetic disorder impacting ion transport.
  • Abnormalities in sodium and chloride movement are central to cystic fibrosis pathology.

Purpose of the Study:

  • To elucidate the physiological role of ion transport.
  • To discuss mechanisms regulating normal sodium and chloride transport.
  • To detail the specific derangements in cystic fibrosis.

Main Methods:

  • Review of physiological transport mechanisms.
  • Analysis of genetic basis of cystic fibrosis.
  • Comparison of normal and diseased ion transport.

Related Experiment Videos

Main Results:

  • Identified increased transepithelial sodium absorption in cystic fibrosis.
  • Observed decreased chloride secretion in cystic fibrosis.
  • Linked ion transport defects to dehydrated pulmonary mucus.

Conclusions:

  • Ion transport is critical for maintaining lung hydration.
  • Defective sodium and chloride transport characterize cystic fibrosis.
  • Understanding these mechanisms is essential for therapeutic strategies.