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Updated: Jul 19, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Solid-phase synthesis of oligoester ion channels
Thomas M Fyles1, Chi-Wei Hu, Horace Luong
1Department of Chemistry, University of Victoria, Victoria, British Columbia, Canada, V8W 3P6. tmf@uvic.ca
Abstract:
A simple synthesis of oligoesters from TBDMS-protected-beta- and THP-protected-omega-hydroxycarboxylic acids using a solid-phase synthesis protocol is reported. Procedures were optimized for the efficient production of ion channel candidates in high purity with minimal purification. The product oligoesters were evaluated for ion transport activity using a fluorescent dye/vesicle assay. Oligoesters produced by this strategy show structure-dependent activity; the most active compounds are closely comparable to previously known oligoesters, but are available at a fraction of the synthetic effort.
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