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Updated: Jul 19, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Epidemiology of fat replacement of the right ventricular myocardium determined by multislice computed tomography
Purpose:
We frequently observe fat replacement (FR) of the anterior wall of the right ventricular myocardium (RVM), but its epidemiological significance is not clear.
Methods And Materials:
49 consecutive subjects (28 males, 36-83 years old, median 67) underwent enhanced ECG-gated multislice CT (Light speed ultra 16, General Electrics, WI) and we retrospectively analyzed the presence of FR of RVM. A logistic model for predicting FR of RVM was constructed using age, sex, hypertension [HT], diabetes mellitus [DM], hyperlipidemia [HL] smoking, obesity (body mass index >25.0) and calcified and non-calcified plaques of coronary arteries (CA).
Results:
FR of RVM was detected in 21 subjects (12 males, 51-78 years old, median 67), 76% of whom had HT, 38% DM, 43% HL, 48% smoking history, 52% were obese, and 76% had calcified and 24% had non-calcified plaques of CA. Only obesity was significantly higher in FR (p<0.05). A logistic regression model showed, although there was a close association between obesity and an increased incidence of FR, it did not reach statistical significance (p=0.0515, relative risk 5.11).
Conclusions:
Obesity is significantly more common in cases of FR, and despite a negative multivariable analysis, may influence FR in the RVM. FR in obesity may occur independently of clinically-significant arrhythmia, which is different from ARVC. Thus, even with FR, obesity must be considered as a diagnosis before ARVC.