Related Experiment Video
Updated: Jul 17, 2026
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
Published on: January 3, 2012
Coagulation profile in Nigerian children with cerebral malaria
T S Akingbola1, W A Shokunbi, P E Olumese
1Department of Haematology, College of Medicine, University of Ibadan, P M B 5116, Nigeria.
Objectives:
To determine the screening coagulation tests - PT, PTT(k), TCT, fibrinogen and absolute platelet counts.
Materials And Methods:
There were 97 children with 35 cerebral malaria (CM) and two control groups 30 acute malaria (AM) and 32 healthy controls aged 6 months--11 years. This is the first documented report of coagulation profile in Nigerian children above 6 months.
Results:
The means of the PT in the three groups were normal. There was no significant difference between the means of PTT(k) and fibrinogen, p values 0.51 and 0.20 respectively. Nine of the CM group had deranged PT while eleven had elevated PTT(k). Four of the thrombocytopaenic CM patients were hypercoagulable. Three CM patients had bleeding episodes without laboratory evidences of DIC. Thrombocytopaenia occurred in 46% of the CM group compared with 23% of the AM. The role of hypercoagulable state observed amongst the thrombocytopaenic CM group could not be determined.
Conclusion:
We suggest close monitoring of platelet count and coagulation profile in those with haemorrhagic complications.
More Related Videos
07:27A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
09:04In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
Related Concept Videos
01:29Malaria
01:29Hemorrhagic Stroke ll: Pathophysiology