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Updated: Dec 12, 2025
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
[Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue]
Lei Cai1, Zi Fen Gao, Xiao Yuan Huang
1Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100083, China.
Objective:
To investigate the clinicopathological and immunohistochemical characteristics of soft tissue mesenchymal chondrosarcoma.
Methods:
The clinical material, pathological and immunohistochemical characteristics (reaction to LCA, CD3, CD20, CD45RO, CD79a, CD99, NSE, S-100, Syn, CgA, CK7, CK19, EMA, Coll-II, Sarcomeric-Actin, Desmin, Ki-67,P53) of 2 cases of soft tissue mesenchymal chondrosarcoma in Jishuitan Hospital between 1995 and 2005 were reviewed and followed up.
Results:
The two patients were both females. The tumors were located in the low extremity muscles. The main roentgenographical appearance was stippled calcification in tumor and calcification at the edge of the tumor. The histological characteristic features showed undifferentiated small cells together with islands of chondrosarcoma; there was hemangiopericytoma-like arrangement of small cells. The tumor cells were positive for CD99, NSE, Syn, CgA; The cells in chondroid matrix were positive for S-100; chondroid matrix was positive for Coll-II. All tumor cells were negative for LCA, CD3, CD20, CD45RO, CD79a,Sarcomeric-actin, Desmin and CK7, CK19, and EMA. The patient with followed radiotherapy was alive. and the other without radiotherapy dead.
Conclusion:
Mesenchymal chondrosarcoma of soft tissue has the characteristics of primary mesenchyme which differentiates to congenital cartilage. The pathological characteristics of bimophic pattern and roentgenographical appearance of tumor are useful for diagnosis. The prognosis is poor.
