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CARP: fishing for novel mechanisms of neovascularization
Susan E Samaras1, Yubin Shi, Jeffrey M Davidson
1Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2561, USA.
Abstract:
Gene expression profiling of mouse skin wounds has led to the discovery of numerous target genes that may have therapeutic or diagnostic value. Among these, cardiac ankyrin repeat protein (CARP, ankrd1) expression was markedly and persistently elevated in several cutaneous compartments. This review summarizes the current state of knowledge of CARP and its regulation in biological systems. In addition to its role as a nuclear transcription cofactor in many cell types including vascular endothelium, CARP is also a structural component of the sarcomere. CARP transcripts are prominent in cardiogenesis and muscle injury, and they are under complex regulation by cytokines, hypoxia, doxorubicin, and other forms of stress. CARP overexpression in wounds by adenoviral gene transfer leads to a high vascular density, and CARP exerts effects on endothelial behavior. The unusual cellular distribution and actions of CARP make it a novel candidate gene in tissue repair.
Insights
Cardiac ankyrin repeat protein (CARP) is elevated in skin wounds. CARP shows potential as a novel therapeutic target for tissue repair due to its effects on vascular density and endothelial cells.
Area of Science:
- Molecular Biology
- Cell Biology
- Biomedical Research
Background:
- Gene expression profiling in mouse skin wounds identified potential therapeutic targets.
- Cardiac ankyrin repeat protein (CARP, ankrd1) showed significant and sustained elevation in cutaneous compartments.
Purpose of the Study:
- To review the current knowledge of CARP and its regulation.
- To explore CARP's role and potential in tissue repair.
Main Methods:
- Literature review of CARP's function, regulation, and expression.
- Analysis of CARP's role in cellular processes, including transcription and structural components.
- Examination of CARP's effects in wound healing models.
Main Results:
- CARP functions as a nuclear transcription cofactor and a sarcomere structural component.
- CARP expression is prominent in cardiogenesis and muscle injury, regulated by stress factors.
- Adenoviral CARP overexpression in wounds increased vascular density and influenced endothelial behavior.
Conclusions:
- CARP's unique cellular distribution and functions position it as a novel candidate for therapeutic intervention in tissue repair.
- Understanding CARP regulation and action is crucial for developing new treatments for wound healing.
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